A new review looks at the history and future of neuromodulation in depression treatment. About 1 in 6 adults in the United States will experience clinical depression at some point during their life. Mainstream treatments do not work well for everyone — researchers estimate that 1–3% of people in the U.S. have treatment-resistant depression. An approach that is much less widely used than either drugs or psychotherapy, known as neuromodulation, aims to correct abnormal communication between the parts of the brain that regulate moods, thoughts, and behaviors.
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